There remain urgent and unmet needs for the treatment of neurological diseases. Epilepsy is a serious, chronic brain disease characterized by recurrent seizures.

Epilepsy is one of the most common serious neurological condition, affecting about 1% of the population, i.e. about 60 million people globally (6 million in Europe).

The end result of PRIME is a software design tool for designing engineered cells that compute, diagnose, and produce therapeutic molecules capable of preventing seizures. The design tool is governed by Artificial Intelligence (AI) integrated with Molecular Communication simulations that utilize Biophysical and Statistical Mechanics modelling. This trans-disciplinary project aims to approach a serious neurological problem through a solution bringing together synthetic biology, computer science, communication engineering, nanomedicine, bioengineering and material science. This vision of implanting programmable synthetic cells that mimic electronic computing circuits is not limited to managing epileptic seizures but may extend to many other neurological diseases.