Authors: Aiman Khalil, Kurt J. A. Pumares, Anne Skogberg, Pasi Kallio, Deirdre Kilbane, and Daniel P. Martins
Members of the EU Fet Open PRIME consortium recently produced a paper titled “Molecular Communications Loss Budget for tsRNA Detection in the Brain,” which has been accepted for publication in the IEEE Transactions on Molecular, Biological, and Multi-Scale Communications (TMBMC).
This study, conducted by Aiman Khalil, PhD Research Students at Walton Institute at South East Technological Institute, under the supervision of Dr. Daniel Perez Martins and Dr. Deirdre Kilbane from Walton Institute, and in collaboration with fellow PhD Student at Walton Kurt J. A. Pumares, and Prof. Pasi Kallio and Anne Skogberg from Tampere University, Finland, as part of the PRIME project, presents a molecular communication (MC) propagation model in a heterogeneous fluidic environment comprising the brain’s extracellular space (ECS) and an implantable biosensing device.
The group investigated how various physicochemical characteristics within each communication channel influence the propagation of epileptic biomarkers. Specifically, they analyzed how these factors contribute to molecular losses within the system, which in turn, affect the sensitivity of epileptic seizure prediction. The model is designed to support the design of bioengineered devices for epileptic seizure prediction by characterizing the propagation of biomarkers.
This innovation is hugely exciting, as the team believes the findings provide a solid foundation for identifying key design parameters that are crucial for optimizing bioengineered sensing devices aimed at predicting epileptic seizures and other neurological diseases.
System Model:
Fig. 1: Schematic illustration of MC between cells in a heterogeneous fluidic environment.
This work was supported by the European Union’s EU-FET Open H2020 PRIME Project under Grant Agreement No. 964712. This publication has emanated from research conducted with the financial support of Taighde Éireann – Research Ireland, under Grant number 21/RC/10294_P2 at FutureNeuro Research Ireland Centre for Translational Brain Science.
Link to the view in full: https://ieeexplore.ieee.org/document/10938710
About PRIME:
EU FET OPEN PRIME project is funded by the European Commission’s Horizon 2020 Research and Innovation programme. The PRIME project aims to prevent epileptic seizures by developing autonomous implantable living cell systems for the brain.
Led by Walton Institute at South East Technological University PRIME project’s consortium of European partners is made up of Tampere University Finland, Università degli Studi di Ferrara Italy, EPOS-IASIS Cyprus, Aarhus University Denmark, omiics Denmark and Royal College of Surgeons in Ireland (RCSI).
